Neuroprotective Effects of Isosteviol Sodium Injection on Acute Focal Cerebral Ischemia in Rats

Figure 4

Therapeutic window characteristics of STVNA treatment in tMCAO. (a) Quantitative analyses of infarct volumes 24 hours after reperfusion. A high infarction volume was seen in the group without STVNA treatment, but the volume was greatly decreased in rats with STVNA administration in a time-dependent manner. (b) Neurologic scores after transient middle cerebral artery occlusion (MCAO) in different groups with STVNA administered at 0, 2, 4, and 6 hours after reperfusion. Neurological deficit scores 24 hours after reperfusion. A high score was seen in the group without STVNA treatment, but the scores were greatly lowered in animals with STVNA administration. Data represent mean ± SEM ( per group). ^∗; ^∗∗ versus vehicle group by 1-way analysis of variance with Tukey’s multiple comparison test.

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