Neuroprotective Effects of Isosteviol Sodium Injection on Acute Focal Cerebral Ischemia in Rats

Figure 6

Effects of STVNA on the histopathology. (a) Brain sections stained by TTC; the P represents the peri-infarct area. (b) Hematoxylin-eosin stains of coronal sections of the brain after 24 hours of reperfusion in the dose-response study groups ( per group). 10 mg: 10 mg/kg STVNA. Scale bar = 100 μm. (c) Effects of STVNA on neuronal immunoreactivity in tMCAO rats ( per group). Scale bar = 50 μm. (d) Effect of STVNA on apoptosis in the rat ischemic brain ( per group). Scale bar = 50 μm. (e) Number of NeuN-immunopositive cells/mm² of brain section. Histograms represent the mean ± the SEM. ^∗ versus vehicle group and versus edaravone group by 1-way analysis of variance with Tukey’s multiple comparison test. (f) Number of TUNEL positive cells/mm² in the brain sections. Histograms represent the mean ± the SEM. ^∗ versus vehicle group by 1-way analysis of variance with Tukey’s multiple comparison test.

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