Neuroprotective Effects of Isosteviol Sodium Injection on Acute Focal Cerebral Ischemia in Rats
Table 1
Physiologic variables in the dose-response study.
Sham
Vehicle
STVNA, mg/kg
Edaravone
1
5
10
20
Before Ischemia (10 minutes)
BR
63.5 ± 4.5
59.6 ± 5.1
63.5 ± 3.2
64.9 ± 1.4
63.3 ± 2.7
63.7 ± 4.0
62.8 ± 4.2
HR
363 ± 14
376.4 ± 7.6
379.4 ± 8.4
375.7 ± 7.8
380.8 ± 10.5
378.4 ± 11.3
374.2 ± 11
SpO2
99.3 ± 0.2
99.3 ± 0.2
99.1 ± 0.3
99.1 ± 0.1
99.2 ± 0.2
99.7 ± 0.1
98.1 ± 0.3
36.2 ± 0.2
36.2 ± 0.3
36.6 ± 0.2
36.0 ± 0.3
36.4 ± 0.3
36.8 ± 0.2
36.4 ± 0.3
After Ischemia (10 minutes)
BR
62.7 ± 5.3
69.4 ± 2.3
63 ± 5.1
70.5 ± 3.4
65.4 ± 1.6
68.4 ± 1.5
63.5 ± 2.6
HR
369 ± 10
378.9 ± 4.5
385.3 ± 5.6
376.7 ± 10
378.7 ± 7.8
390.2 ± 7.5
375 ± 8.4
SpO2
99.3 ± 0.1
99.3 ± 0.1
99.1 ± 0.2
98.9 ± 0.1
98.9 ± 0.2
99.4 ± 0.2
98.8 ± 0.3
36.4 ± 0.2
36.7 ± 0.1
36.3 ± 0.3
36.9 ± 0.3
36.5 ± 0.2
37.3 ± 0.1
36.2 ± 0.3
Before reperfusion (10 minutes)
BR
72.5 ± 2.5
70 ± 1.5
69.5 ± 1.0
71.8 ± 1.5
70.2 ± 2.7
71.3 ± 1.6
67.8 ± 2.3
HR
377 ± 10
390 ± 5.8
400 ± 6.9
405 ± 8.5
400.2 ± 6.6
398.2 ± 9.6
402.5 ± 5.6
SpO2
99.4 ± 0.1
99.4 ± 0.1
99.5 ± 0.1
99.4 ± 0.1
99.5 ± 0.1
99.0 ± 0.2
99.4 ± 0.1
36.2 ± 0.2
37.9 ± 0.2
38.2 ± 0.1
37.9 ± 0.3
38.0 ± 0.1
38.1 ± 0.2
38.3 ± 0.1
After reperfusion (10 minutes)
BR
73.2 ± 3.2
68.6 ± 2.4
72.6 ± 1.4
72.3 ± 1.9
72.1 ± 3.1
70.5 ± 1.5
69.8 ± 3.2
HR
387 ± 9
401.4 ± 8.4
401.7 ± 2.9
397.1 ± 5.5
396.7 ± 7.8
408.7 ± 4.1
394 ± 10
SpO2
99.3 ± 0.1
98.3 ± 0.1
98.7 ± 0.4
99.4 ± 0.1
99.5 ± 0.1
99.7 ± 0.1
99.4 ± 0.1
37.5 ± 0.1
37.6 ± 0.3
37.9 ± 0.2
37.8 ± 0.1
37.6 ± 0.1
37.0 ± 0.1
37.8 ± 0.2
All of the data were shown as the mean ± the SEM (). BR: breathing rate (breaths/min); HR: heart rate (beats/min); : temperature (°C); SpO2: Pulse Oximeter Oxygen Saturation (%).
