Uncoupling of Vascular Nitric Oxide Synthase Caused by Intermittent Hypoxia

Figure 1

Endothelium-dependent and endothelium-independent relaxation responses in diabetic and nondiabetic mice aortic tissues after 8 weeks of CIH or IA. Cumulative concentration response curve to ACh (a) and maximum relaxation response to ACh (b). Cumulative concentration response curve to SNP (c). Values are displayed as mean ± SD and represent = 5–8 mice. Statistical analysis was done using two-way repeated measures ANOVA followed by Bonferroni posttest. versus IA, versus IH, and versus IADB. ACh = acetylcholine, SNP = sodium nitroprusside, and PE = phenylephrine.

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