Uncoupling of Vascular Nitric Oxide Synthase Caused by Intermittent Hypoxia

Figure 2

Effect of CIH on basal NO production in diabetic and nondiabetic mice. Cumulative concentration response curves to PE before and after adding L-NAME (a, b, c, d). AUC calculated for the contraction response to PE after adding L-NAME (e). Values are displayed as mean ± SD and represent = 5–8 mice. Statistical analysis was done using two-way repeated measures ANOVA followed by Bonferroni posttest. versus IA, versus IH, and versus IADB. ACh = acetylcholine, AUC = area under the curve, L-NAME = N_ω-nitro-L-arginine methyl ester, and PE = phenylephrine.

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