Modulation of Tamoxifen Cytotoxicity by Caffeic Acid Phenethyl Ester in MCF-7 Breast Cancer Cells

Figure 7

Expression levels of Bcl-2, Beclin 1, and VEGF in MCF-7 cells. Expression levels of Bcl-2, Beclin 1, and VEGF after 24 h (a, c, and e) and 48 h (b, d, and f) treatments with TAM (10 μM), CAPE (4 μM), and their combination. Results were expressed as relative expression of 3 independent experiments performed in triplets. Values of each bar are means ± SD. GAPDH was used as an internal control for calculating mRNA relative expression. A: significantly different from the respective concentration of control at . B: significantly different from the respective concentration of TAM at . C: significant difference of 48 h treatment from the respective concentration at 24 h at .

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