Protective Effect of Peroxisome Proliferator-Activated Receptor α Activation against Cardiac Ischemia-Reperfusion Injury Is Related to Upregulation of Uncoupling Protein-3

Figure 5

H9c2 cells treated with WY-14643 were more resistant against hypoxia-reoxygenation injury. Cells were incubated with medium containing 0 to 100 μM of WY-14643 for 24 h before 20 h of hypoxia and 2 h of reoxygenation. MTT assay shows that cell viability was increased with treatment of WY-14643 10 μM or greater. versus WY-14643 0 μM (). versus WY-14643 0 μM (). HR: hypoxia-reoxygenation.