Calcium Oxalate Induces Renal Injury through Calcium-Sensing Receptor

Figure 5

Representative microscopic photographs showing crystal deposits and pathological changes in rat kidneys. (a) The control group rats were fed a standard diet and served as the intact control group. (b) The EG group rats were fed a standard commercial diet with 1% ethylene glycol for 28 days to induce nephrolithiasis. (c) The EG+GdCl₃ group rats received EG and were injected with 8.67 mg/kg/day GdCl₃ for 4 weeks. (d) The EG+NPS2390 group rats received EG and were injected with 0.20 g/kg NPS2390 for 4 weeks. (e) Scores for crystal deposition and pathological alterations. The columns and bars represent the mean ± SEM ( compared with the EG group, magnification: 100, ).

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