Research Article
PAN-811 Blocks Chemotherapy Drug-Induced In Vitro Neurotoxicity, While Not Affecting Suppression of Cancer Cell Growth
Figure 5
Effects of PAN-811⋅Cl⋅H2O on anticancer drug-induced cytotoxicities to human cancer cell H460. (a) Phase contrast photographs for the H460 cells that received 25 μM 5-FU, 10 μM PAN-811, or both for 3 days (bar = 50 μm). (b)–(d) MTS analysis for the H460 cells that received 10 μM PAN-811⋅Cl⋅H2O, one of 100 μM MTX, 25 μM 5-FU, and 3.5 μM CDDP, or both 10 μM PAN-811⋅Cl⋅H2O and one of these anticancer drugs for 3 days, respectively (). (e)–(g) LDH analysis for (b)–(d) (). Data are expressed as % of noninsulted/untreated control. Figure symbol is , < 0.01, compared with noninsult/untreated control group by one-factor ANOVA followed with Tukey HSD test. §§, between no insult and insult groups given PAN-811 by Student’s t-test.
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