CLOCK Promotes Endothelial Damage by Inducing Autophagy through Reactive Oxygen Species

Figure 6

Schematic representation of CLOCK in hypoxia response. Hypoxia induced the expression of CLOCK, leading to ROS production in vascular endothelial cells. Increased cellular ROS resulted in excessive autophagy, which finally contributed to cell apoptosis and even cell death. Tiron, a ROS scavenger, decreased ROS production, which attenuated excessive autophagy.