Platelet Carbonic Anhydrase II, a Forgotten Enzyme, May Be Responsible for Aspirin Resistance

Table 1

Baseline demographic characteristics and biochemical stratification of cardiovascular risk in subgroups separated according to the ASA response.

—	Aspirin resistant (AR) (mean ± SEM)	Aspirin sensitive (AS) (mean ± SEM)
N	36–	25–
Women [%]	22 (61%)	5 (20%)
Age [y]	30.28 ± 1.74	29.16 ± 1.81	0.41
BMI [kg/m^2]	22.87 ± 0.61	24.11 ± 0.67	0.10
WBC [k/μl]	5.77 ± 0.22	5.66 ± 0.26	0.80
RBC [mln/μl]	4.68 ± 0.08	4.94 ± 0.09	0.02
Hemoglobin [g/dl]	13.96 ± 0.25	14.74 ± 0.30	0.03
Hematocrit [%]	40.12 ± 0.64	42.12 ± 0.69	0.05
MCV [fl]	85.89 ± 0.51	86.10 ± 0.67	0.82
MCH [pg]	29.86 ± 0.20	30.09 ± 0.35	0.46
MCHC [g/dl]	34.77 ± 0.15	34.95 ± 0.22	0.54
PLT [k/μl]	236.72 ± 9.98	213.76 ± 9.32	0.12
PDW [fl]	13.79 ± 0.37	13.55 ± 0.46	0.50
Glucose [mg/dl]	83.39 ± 1.07	88.52 ± 2.06	0.03
Creatinine [mg/dl]	0.96 ± 0.02	1.11 ± 0.03	<0.001
eGFR [ml/min]	82.78 ± 1.51	79.76 ± 1.84	0.25
Uric acid [mg/dl]	7.25 ± 1.68	5.49 ± 0.22	0.18
hsCRP [mg/l]	1.77 ± 0.44	0.74 ± 0.18	0.06
Total cholesterol [mg/dl]	179.97 ± 6.16	190.52 ± 6.38	0.35
HDL [mg/dl]	54.25 ± 1.89	53.20 ± 1.87	0.89
LDL [mg/dl]	105.72 ± 5.62	115.96 ± 5.47	0.26
Triglycerides [mg/dl]	90.42 ± 7.97	106.84 ± 15.71	0.71
Sodium [mmol/l]	137.83 ± 0.27	138.16 ± 0.26	0.54
Potassium [mmol/l]	4.04 ± 0.04	4.18 ± 0.05	0.10

BMI: body mass index; WBC: white blood cells; RBC: red blood cells; MCV: mean (red blood) cell volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; PLT: platelets; PDW: platelet distribution width; eGFR: estimated glomerular filtration rate; hsCRP: high-sensitivity C-reactive protein; HDL: high-density lipoprotein; LDL: low-density lipoprotein.