Antioxidants of Phyllanthus emblica L. Bark Extract Provide Hepatoprotection against Ethanol-Induced Hepatic Damage: A Comparison with Silymarin

Table 5

Effect of PEE on ALT, AST, ALP, and TP in ethanol-induced liver damage in rats.

Study groups	Treatment; administered	ALT	AST	ALP	TP
Normal control	Saline (1 mL/kg/day)	49.49 ± 4.647	155.4 ± 6.197	270.71 ± 48.66	5.2 ± 0.31
Disease control	70% ethanol (10 mL/kg/day)	103.9 ± 16.33^###	301.8 ± 17.91^###	396.4 ± 17.07^#	3.017 ± 0.31^###
SIL25	Silymarin (25 mg/kg/day)	56.20 ± 1.953	230.5 ± 21.65	278.6 ± 4.351	4.9 ± 0.50
PEE500	PEE (500 mg/kg/day)	61.20 ± 4.693	189.8 ± 8.84	267.1 ± 14.15	5.283 ± 0.25
PEE1000	PEE (1000 mg/kg/day)	69.03 ± 3.66	210.8 ± 17.82	360.9 ± 44.92	5.133 ± 0.35

ALT: alanine aminotransferase, AST: aspartate aminotransferase, ALP: alkaline phosphatase, and TP: total protein. All values are expressed as mean ± SEM of at least 6 animals from each experimental group. Data found significant when One Way ANOVA followed by Dunnett’s multiple comparison test performed. was considered to be significant. Statistical significance (^#; ^##; ^###) compared with the normal control group and (; ; ) compared with the disease control group.