Antioxidants of Phyllanthus emblica L. Bark Extract Provide Hepatoprotection against Ethanol-Induced Hepatic Damage: A Comparison with Silymarin

Table 6

Effect of PEE on histopathological activity index in ethanol-induced liver damage in rats.

Study groups	Sinusoidal congestion in hepatic parenchyma	Degenerative changes; of hepatocytes,; cellular swelling,; vacuolar changes with granular cytoplasm of hepatocytes	Necrotic changes of hepatic parenchyma, loss of nucleus, fragmentation of nuclei, centrilobular, midzonal necrosis	Bile duct hyperplasia	Perivascular lymphoid aggregation	Infiltration of mononuclear cells (MNC), formation of microgranuloma	Fatty liver (lipid deposition in hepatocyte), steatosis	Overall pathological grade; (lesion score)
Normal control	+/focal	NAD	NAD	NAD	+/focal	NAD	+/focal	NAD
Disease control	++	+ ++	++	+	+	NAD	++	+++
SIL25	NAD	+/focal	NAD	NAD	NAD	NAD	NAD	+
PEE500	NAD	+/focal	+/focal	+	NAD	+/focal	NAD	++
PEE1000	NAD	+	+	+/focal	NAD	NAD	NAD	+

per experimental group. No abnormality detected (NAD), minimal pathological changes (+), mild pathological changes (++), moderate pathological changes (+++), and severe pathological changes (++++). Focal and minimal changes may not be significant for alteration of functional capacity of the organ.