MicroRNAs Modulate Oxidative Stress in Hypertension through PARP-1 Regulation

Figure 5

miR-103-2-5p and miR-585-5p decrease colony formation and cell survival. (a, b) HAECs transfected with miR-103a-2-5p, miR-585-5p, or scrambled control (Scr.) were plated, and 24 hrs later, cells were either untreated or treated with 50 μM H₂O₂. After 7 days, colony formation was imaged and quantified. (c) HAECs were treated with 100 μM H₂O₂ for 24 hrs, and cell survival was measured by the MTT assay. The histograms are normalized to Scr untreated and represent the mean + SEM from three independent experiments. , , by Student’s t-test.

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