Baicalin Ameliorates Liver Injury Induced by Chronic plus Binge Ethanol Feeding by Modulating Oxidative Stress and Inflammation via CYP2E1 and NRF2 in Mice

Figure 4

Baicalin treatment ameliorates against chronic-binge ethanol-induced liver injury by attenuating liver inflammation. Liver mRNA levels determined by real-time PCR of TNF-α (a), IL-1β (b), MIP-2 (c), and MCP-1 (d). The results are expressed as fold change relative to the pair-fed group. Values represent means ± SEM and /group. versus pair-fed group, ^# versus EtOH group. (e) Transcriptional activity of NF-κB were determined and represented as fold change. Values represent means ± SEM and /group. versus pair-fed group, ^# versus EtOH group. (f) TNF-α in Kupffer cell culture supernatant determined by ELISA assay. Values represent means ± SEM and /group. versus control, ^# versus LPS + Veh group.

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