Fucoxanthin, a Marine Carotenoid, Attenuates β-Amyloid Oligomer-Induced Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells

Figure 1

Fucoxanthin attenuated Aβ oligomer-induced neuronal loss as evidenced by the MTT assay. (a) Aβ oligomers induced neuronal loss in a concentration-dependent manner in SH-SY5Y cells. SH-SY5Y cells were treated with Aβ oligomers at various concentrations as indicated. After 24 h, the MTT assay was used to measure cell viability. (b) Fucoxanthin attenuates Aβ oligomer-induced neuronal loss in SH-SY5Y cells. SH-SY5Y cells were treated with fucoxanthin at various concentrations as indicated. After 2 h, 1 μM Aβ oligomer was added. The MTT assay was used to measure cell viability at 24 h after the addition of Aβ oligomers. Data, expressed as percentage of control were the mean ± SEM of three separate experiments; ^## versus the control group in (b), versus the control group in (a) and the Aβ oligomer group in (b) (ANOVA and Tukey’s test).

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