Fucoxanthin, a Marine Carotenoid, Attenuates β-Amyloid Oligomer-Induced Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells

Figure 6

SB415286 and U0126 synergistically attenuates Aβoligomer-induced neuronal loss in SH-SY5Y cells. SH-SY5Y cells were treated with SB415286, a GSK3β inhibitor, and/or U0126, a MEK inhibitor, at various concentrations as indicated. After 2 h, 1 μM Aβ oligomer was added. The MTT assay was used to measure cell viability at 24 h after the treatment of Aβ oligomers. Data, expressed as percentage of control were the mean ± SEM of three separate experiments; ^## versus the control group, and versus the Aβ oligomer group; ^$ versus the U0126 plus Aβ oligomer group (ANOVA and Tukey’s test).