Pathway-Driven Approaches of Interaction between Oxidative Balance and Genetic Polymorphism on Metabolic Syndrome

Table 7

Pathway-based analysis for interaction between OBS and genetic variation for metabolic syndrome.

Resources	Biological process	Description	value	FDR	Significant genes/selected genes/all genes
KEGG; Hsa04370	VEGF signaling pathway	Genes involved in VEGF signaling pathway.	<0.001	0.020	25/54/70
KEGG; Hsa00480	Glutathione metabolism	Genes involved in glutathione metabolism	<0.001	0.022	12/26/39
Biocarta	Rac-1 pathway	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures	<0.001	0.045	14/20/22
Biocarta	Rho pathway	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellipodia	0.001	0.062	14/25/31
Biocarta	TNFR1 pathway	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis	0.005	0.085	13/23/29