Nicotinamide Adenine Dinucleotide Protects against Spinal Cord Ischemia Reperfusion Injury-Induced Apoptosis by Blocking Autophagy

Figure 3

Basso, Beattie, and Bresnahan (BBB) scores of rats in ischemia reperfusion (I/R), 10 mg/kg nicotinamide adenine dinucleotide (NAD⁺), and 75 mg/kg NAD⁺ group at each time point. BBB scores were measured from 1 h to 24 h after I/R injury. Compared with the I/R group, BBB scores were consistently higher in 75 mg/kg NAD⁺-treated rats from 6 to 24 h after I/R injury, whereas there were no significant differences in the 10 mg/kg NAD⁺ group from 1 h to 24 h after injury. Values are means ± SD ( per group). versus I/R; versus I/R.