African Ancestry Gradient Is Associated with Lower Systemic F₂-Isoprostane Levels

Table 3

Association between plasma F₂-isoprostanes and African ancestry gradient.

	Beta coefficient (SE)
	value
	Model 1		Model 2		Model
			A	B	A	B
AA (versus NHW)	−29.1 (4.3)	−0.436 (0.066)	−30.9 (4.4)	−0.468 (0.076)	−30.3 (4.4)	−0.456 (0.076)
	<0.001	<0.001	<0.001	<0.0001	<0.001	<0.0001
AA (versus WAI)	15.8 (4.5)	0.349 (0.069)	9.8 (4.5)	0.263 (0.077)	9.8 (4.5)	−0.265 (0.077)
	0.001	<0.001	0.03	0.0008	0.03	0.0007
Age (years)	−0.06 (0.1)	−0.001 (0.002)
	0.65	0.69
Sex (males versus females)	−5.3 (3.5)	−0.048 (0.054)
	0.13	0.37
BMI (kg/m^2)	1.02 (0.3)	0.016 (0.004)	0.2 (0.3)	0.006 (0.005)	Excluded	Excluded
	<0.001	0.0001	0.40	0.22
Morbidity score			3.15 (1.7)	0.051 (0.027)
			0.07	0.06	0.01	0.007

-isoprostane variable presents the measurements on the original scale in A and on the natural log-transformed scale in B.
Model 3, obesity (BMI ≥ 30) was included in morbidity index.