PPAR-γ Activation Prevents Septic Cardiac Dysfunction via Inhibition of Apoptosis and Necroptosis

Figure 6

Expressions of inhibitor κB (IκBα), NF-κB, and proinflammatory cytokines in the myocardium of septic rats. Rats were treated with or without rosiglitazone (ROT) or T007 before CLP and were sacrificed 18 hours after CLP. (a, b) Protein expressions of nuclear IκBα and NF-κB and (c) mRNA levels of proinflammatory cytokines, tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and interleukin 1β (IL-1β) were assessed in the myocardium. , versus sham. ^#, ^## versus CLP. Data are presented as mean ± SEM. per group.

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