PPAR-γ Activation Prevents Septic Cardiac Dysfunction via Inhibition of Apoptosis and Necroptosis

Figure 7

Necroptosis in the myocardium of rats after CLP. Myocardiums of rats subjected to CLP with or without pretreatment of rosiglitazone (ROT) or T007 were collected 18 hours after CLP. Necroptosis in myocardium was assessed by evaluating protein expressions of receptor-interacting protein kinase-1 (RIP1), RIP3, and mixed lineage kinase-like (MLKL) domain, which are the three key components of necroptosis. versus sham. ^#, ^## versus CLP. Data are presented as mean ± SEM. per group.

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