Mechanism of Mechanical Trauma-Induced Extracellular Matrix Remodeling of Fibroblasts in Association with Nrf2/ARE Signaling Suppression Mediating TGF-β1/Smad3 Signaling Inhibition

Figure 9

In vivo confirmation on vaginal distension-induced SUI mice model. (a) LPPs of mice in six groups. (b, c) Protein expression levels of TGF-β1/Smad3 signaling and ECM in anterior vaginal walls of mice in six groups. (d) MDA concentrations in anterior vaginal walls of mice in six groups. compared with the WT-VD group. ^# compared with the KO-VD group; every experiment was repeated for 3 times. WT-NC: noninstrumented control group of wild-type mice; WT-Sham: sham-operated group of wild-type mice; WT-VD: VD group of wild-type mice; KO-NC: noninstrumented control group of Nrf2 knockout mice; KO-Sham: sham-operated group of Nrf2 knockout mice; KO-VD: VD group of Nrf2 knockout mice.

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