The Protective Effect of Indole-3-Acetic Acid (IAA) on H<sub>2</sub>O<sub>2</sub>-Damaged Human Dental Pulp Stem Cells Is Mediated by the AKT Pathway and Involves Increased Expression of the Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) and Its Downstream Target Heme Oxygenase 1 (HO-1)

<div>Proposed mechanisms of action of IAA in H<sub>2</sub>O<sub>2</sub>-exposed human dental pulp stem cells. IAA treatment may have an antiapoptotic effect and protect against H<sub>2</sub>O<sub>2</sub>-induced oxidative stress by increasing the expression of Nrf2 and HO-1, mediated by the AKT pathway.</div>

Oxidative Medicine and Cellular Longevity

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Figure 7

Figure 7: The Protective Effect of Indole-3-Acetic Acid (IAA) on H<sub>2</sub>O<sub>2</sub>-Damaged Human Dental Pulp Stem Cells Is Mediated by the AKT Pathway and Involves Increased Expression of the Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) and Its Downstream Target Heme Oxygenase 1 (HO-1) 

Figure 7 | The Protective Effect of Indole-3-Acetic Acid (IAA) on H2O2-Damaged Human Dental Pulp Stem Cells Is Mediated by the AKT Pathway and Involves Increased Expression of the Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) and Its Downstream Target Heme Oxygenase 1 (HO-1) 