Deficiency of the Purinergic Receptor 2X₇ Attenuates Nonalcoholic Steatohepatitis Induced by High-Fat Diet: Possible Role of the NLRP3 Inflammasome

Figure 2

NASH grading and staging. Hematoxylin and eosin ((a); original magnification 250x) and Masson’s trichrome ((c); original magnification 250x) staining of liver sections from representative animals; and NASH grading (c) and staging (d) in the HFD-fed WT () and Pr2x₇^−/− () mice fulfilling NASH criteria. P = portal space; CV = centrolobular vein; B = ballooning degeneration; M = Mallory’s body; INF = inflammation. NASH = nonalcoholic steatohepatitis; HFD = high-fat diet; WT = wild type; Pr2x₇^−/− = knockout for purinergic receptor 2X₇ gene.

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