Deficiency of the Purinergic Receptor 2X₇ Attenuates Nonalcoholic Steatohepatitis Induced by High-Fat Diet: Possible Role of the NLRP3 Inflammasome

Figure 4

Hepatic PR2X₇ expression. Immunohistochemistry for PR2X₇ in liver sections from representative animals ((a); original magnification 100x) and quantification of liver PR2X₇ protein content (b), Pr2x₇ mRNA expression (c), and eATP levels (d) in NFD- and HFD-fed WT and P2x₇r^−/− mice (mean ± SD; per group). P = portal space; > = parenchymal cell (hepatocyte) staining; → = nonparenchymal (sinusoidal lining) cell staining. or versus NFD-fed mice; ^‡ versus WT mice. PR2X₇ = purinergic receptor 2X₇; Pr2x₇ = PR2X₇ gene; eATP = extracellular ATP; NFD = normal-fat diet; HFD = high-fat diet; WT = wild type.

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