Deficiency of the Purinergic Receptor 2X₇ Attenuates Nonalcoholic Steatohepatitis Induced by High-Fat Diet: Possible Role of the NLRP3 Inflammasome

Figure 8

Potential mechanisms involved in PR2X₇-mediated expression/activation of the NLRP3 inflammasome. CML = N^ε-(carboxymethyl)lysine; DAMPs = damage-associated molecular patterns; eATP = extracellular ATP; ER = endoplasmic reticulum; FFAs = free fatty acids; IL-1β = interleukin-1β; LDLs = low density lipoprotein; MVs = microvesicles; NADPH ox = NADPH oxidase; NF-κB = nuclear factor-κB; NLRP3 = nucleotide-binding and oligomerization domain (NOD), leucine-rich repeat and pyrin domain containing 3; PR2X₇ = purinergic receptor 2X₇; PYCARD = the PYD-CARD adaptor protein apoptosis-associated speck-like protein containing a caspase recruitment domain; RAGE = receptor for advanced glycation end products; ROS = reactive oxygen species; TLR = toll-like receptor; TNF-α = tumor necrosis factor-α.