Deficiency of the Purinergic Receptor 2X₇ Attenuates Nonalcoholic Steatohepatitis Induced by High-Fat Diet: Possible Role of the NLRP3 Inflammasome

Table 1

Metabolic parameters and liver enzymes. Body weights and levels of glucose, insulin, HOMA-IR index, cholesterol, triglycerides, FFAs, AST, and ALT in WT and Pr2x₇^−/− mice fed with a NFD or a HFD (mean ± SD; per group).

	WT-NFD	Pr2x7^−/−-NFD	WT-HFD	Pr2x7^−/−-HFD
Body weight, g	31.8 ± 2.3	32.6 ± 1.9	41.2 ± 5.5	40.6 ± 1.5
Glucose, mmol·l^−1	5.56 ± 0.88	5.63 ± 0.73	9.01 ± 0.71	8.85 ± 1.08
Insulin, pmol·l^−1	63.9 ± 18.7	58.3 ± 11.5	158.1 ± 18.1	151.9 ± 19.1
HOMA-IR	2.21 ± 0.79	2.05 ± 0.56	8.84 ± 1.32	8.38 ± 1.86
Cholesterol, mmol·l^−1	2.64 ± 0.31	2.62 ± 0.54	3.93 ± 0.62	3.82 ± 0.31
Triglycerides, mmol·l^−1	0.56 ± 0.21	0.57 ± 0.17	1.78 ± 0.52	1.42 ± 0.29
FFA, mEq·l^−1	0.33 ± 0.05	0.31 ± 0.06	0.95 ± 0.11	0.83 ± 0.09
AST, UI·l^−1	33.6 ± 5.6	31.3 ± 4.6	87.1 ± 12.3	55.9 ± 7.1^†
ALT, UI·l^−1	22.6 ± 7.2	18.6 ± 3.6	111.4 ± 18.4	58.3 ± 15.7^†

HOMA-IR = homeostasis model assessment-insulin resistance; FFAs = free fatty acids; AST = aspartate transaminase; ALT = alanine transaminase; WT = wild type; Pr2x₇^−/− = knockout for purinergic receptor X2₇ gene; NFD = normal-fat diet; HFD = high-fat diet. versus the corresponding NFD-fed mice; versus WT mice.