NPC-EXs Alleviate Endothelial Oxidative Stress and Dysfunction through the miR-210 Downstream Nox2 and VEGFR2 Pathways

Figure 3

Up- or downregulation of miR-210 modulated the effects of NPC-EXs on reducing Ang II-induced apoptosis and ROS overproduction in ECs. (a) The apoptotic rate of ECs treated with different NPC-EXs. (b) Up: representative images showing DHE staining of ECs treated with different NPC-EXs; bar: 100 μm; bottom: summarized data; versus con; ⁺ versus vehicle; ^# versus NPC-EXs^con or NPC-EXs^sc; ^& versus NPC-EXs^anti-miR-210. EXs released from NPCs^con, NPCs^sc, NPC-EXs^anti-miR-210, or NPCs^miR-210 were denoted as NPC-EXs^con, NPC-EXs^sc, NPC-EXs^anti-miR-210, or NPC-EXs^miR-210. Data are expressed as mean ± SEM. /group.

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