Pyrrolidine Dithiocarbamate (PDTC) Inhibits DON-Induced Mitochondrial Dysfunction and Apoptosis via the NF-κB/iNOS Pathway

Figure 4

PDTC protects cells from DON-induced mitochondrial injury in GH3 cells. Cells were treated with DON, PDTC, and PDTC pretreatment, followed by treatment with DON for 12 hours. (a, e) Cell treated with DON showing normal mitochondria. (b, f) Cell treated with PDTC showing normal mitochondria. (c, g) Cells with PDTC pretreatment, followed by treatment with DON for 12 hours showing normal mitochondria and tiny vacuoles.

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