Pyrrolidine Dithiocarbamate (PDTC) Inhibits DON-Induced Mitochondrial Dysfunction and Apoptosis via the NF-κB/iNOS Pathway

Figure 6

A proposed mechanism of action for the protective effect of PDTC in DON-mediated mitochondrial dysfunction and apoptosis. DON indirectly activates the NF-κB signal pathway via the classical route of IκB/NF-κB p65 signaling. PDTC inhibits the translocation of NF-κB p65 and the transcription of iNOS, and thereby protects cells from mitochondrial dysfunction and cell apoptosis.