Pyrrolidine Dithiocarbamate (PDTC) Inhibits DON-Induced Mitochondrial Dysfunction and Apoptosis via the NF-κB/iNOS Pathway

Table 1

Activities of GSH-Px, GST, CAT, and SOD in GH3 cells.

Group (ng/mL)	CAT activity (U/mg protein)	SOD (U/mL)	GSH-Px (U/mg protein)	MDA (μmol/mg protein)
0	0.407 ± 0.008	1.907 ± 0.224	150.262 ± 0.001	1.476 ± 0.023
300	0.949 ± 0.012	2.938 ± 0.426	134.592 ± 0.034	1.736 ± 0.032
600	1.129 ± 0.006	4.630 ± 0.075	85.149 ± 0.217	1.698 ± 0.038
1200	2.326 ± 0.005	5.798 ± 0.257	53.719 ± 0.421	1.777 ± 0.042

Note: CAT 1 U = the amount of enzyme that consumes 1 nmole H₂O₂/min. GST 1 U = the amount of enzyme that conjugates 1 μmole CDNB/min. GSH-Px 1 U = the amount of enzyme that converts 1 μM GSH to GSSG in the presence of H₂O₂/min. SOD 1 U = the amount of enzyme required for 50% inhibition of pyrogallol autooxidation. Data are shown as means ± SD () from three separate experiments performed in triplicate. indicates values < 0.05, and indicates values < 0.01.