Honokiol Protects against Anti-<i>β</i>1-Adrenergic Receptor Autoantibody-Induced Myocardial Dysfunction via Activation of Autophagy

<div>Honokiol activated autophagy in myocardial tissues after passive immunization. (a) Representative Western blot images of autophagic markers LC3I, LC3II, Beclin-1, and p62 in cardiac tissue lysates from each group. (b–d) Quantification and comparison of Western blot band values from (a). In the <i>β</i>1-AAB group, LC3II and Beclin-1 decreased and p62 increased. These protein levels changed in the opposite direction in the <i>β</i>1-AAB + HNK group. 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id="g113-54"></path></g></svg> relative to the control group. <svg height="12.1645pt" id="M13" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -11.5275 49.7858 12.1645" width="49.7858pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z" id="g58-33"></path></g><g transform="matrix(.013,0,0,-0.013,4.946,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z" id="g113-81"></path></g><g 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HNK: honokiol.</div>

Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Honokiol Protects against Anti-<i>β</i>1-Adrenergic Receptor Autoantibody-Induced Myocardial Dysfunction via Activation of Autophagy 

Oxidative Medicine and Cellular Longevity

Honokiol Protects against Anti-β1-Adrenergic Receptor Autoantibody-Induced Myocardial Dysfunction via Activation of Autophagy

Figure 6