VDR Agonist Prevents Diabetic Endothelial Dysfunction through Inhibition of Prolyl Isomerase-1-Mediated Mitochondrial Oxidative Stress and Inflammation

Table 1

Effects of vitamin D treatment on circulatory levels of Pin1, MDA, SOD, IL-1β, IL-6, and NO of diabetic mice.

Group	Pin1 (ng/mL)	MDA (nmol/L)	SOD (U/mL)	IL-1β (ng/mL)	IL-6 (pg/mL)	NO (μM)
Control	34.3 ± 1.2	7.4 ± 1.0	224.1 ± 35.3	38.1 ± 7.0	64.5 ± 14.2	36.7 ± 3.1
DM	52.3 ± 4.5	15.7 ± 0.7	128.5 ± 10.7	71.9 ± 8.4	96.4 ± 10.6	10.2 ± 1.4
VitD	43.6 ± 3.4^#	8.2 ± 1.0^#	201.0 ± 21.1^#	53.3 ± 9.9^#	86.2 ± 17.5^#	27.0 ± 2.9^#
Juglone	36.8 ± 6.3^#+	11.7 ± 0.9^#+	163.5±22.0^#+	53.9±6.4^#	83.4±14.4^#	25.8±2.7^#

Note: each group; versus control; versus DM; versus VitD.