Long-Term Administration of Angiotensin (1–7) to db/db Mice Reduces Oxidative Stress Damage in the Kidneys and Prevents Renal Dysfunction

Figure 2

Oxidative stress damage in the kidneys from animals treated for 16 weeks. Damage due to oxidative stress was assessed using sections immunostained for nitrotyrosine residues. Representative images of kidney cortex taken at 10x magnification are shown in (a). Significantly, more staining was observed in the kidneys from diabetic animals treated with saline than in nondiabetic groups. 16 weeks of A(1–7) administration to db/db mice reduced oxidative stress damage in the kidneys (b). (hzg: heterozygous; animals per group; and ) Calculated using one-way ANOVA; plotted as mean with SEM.

(a)

(b)