Isobavachalcone Induces ROS-Mediated Apoptosis <i>via</i> Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells

<div>IBC directly binds and inactivates TrxR1 in PC-3 cells. (a) The activity of the TrxR1 enzyme. (b) The TrxR1 expression was determined by Western blotting after knockdown with siRNAs for 12 h. (c) Knockdown of TrxR1 in PC-3 cells significantly increased the ROS levels (d) and apoptotic cells. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Isobavachalcone Induces ROS-Mediated Apoptosis <i>via</i> Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells 

Oxidative Medicine and Cellular Longevity

Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells

Figure 4