Glycine Increases Insulin Sensitivity and Glutathione Biosynthesis and Protects against Oxidative Stress in a Model of Sucrose-Induced Insulin Resistance

Figure 5

Effect of glycine treatment on the IR-β and IRS1 phosphorylation (p-IR-β and p-IRS1) in tyrosine and serine residues induced by acute insulin administration (100 nmol/kg body weight) and of total IR-β and IRS1 in rat liver homogenates from both C and SF rats. Values in the panels correspond to the ratio OD of p-IR-β/OD of total IR-β (a, b) and to the ratio OD of p-IRS1/OD of total IRS1 (c, d). Data are expressed as the mean ± SD ( different rats). compared to the C group and compared to the CG group. compared to the SF group and compared to the SFG group. ^$ compared to the C + I group and ^$$ compared to the SF + I, C + I (control + insulin), SF + I (sucrose-fed + insulin), CG + I (control + glycine + insulin), and SFG + I (sucrose fed + glycine + insulin) groups.

(a)

(b)

(c)

(d)