Indoleamine 2,3-Dioxygenase-Dependent Neurotoxic Kynurenine Metabolism Contributes to Poststroke Depression Induced in Mice by Ischemic Stroke along with Spatial Restraint Stress

Figure 7

Effect of aripiprazole on Iba-1(+) cells or IDO1(+)/Iba-1(+) cells in PSD mice. The number of Iba-1(+) cells (a) or IDO(+)/Iba-1(+) cells (b) was determined by immunofluorescent staining of the nucleus accumbens (NAc), hippocampus (Hippo), and hypothalamus (Hypo) from control, sham (PSD), and aripiprazole-treated mice (PSD + APZ). Aripiprazole-treated PSD mice showed markedly lower numbers of IDO(+)/Iba-1(+) cells than did PSD mice. Data are expressed as (). , , and vs. control; , , and vs. PSD.

(a)

(b)