Pretreatment with Shuanghe-Tang Extract Attenuates Postischemic Brain Injury and Edema in a Mouse Model of Stroke: An Analysis of Medicinal Herbs Listed in Dongui Bogam

Figure 3

Effects of Shuanghe-tang and Zengsunsiwu-tang on brain function and behavior following ischemic brain injury. (a) Mice were pretreated via oral administration of 500 mg/kg of Shuangh-tang or Zengsunsiwu-tang () or PBS (control group, ) once per day for 4 days prior to ischemic injury, as well as 1 h prior to the procedure. Twenty-four hours after ischemic brain injury, the mouse brains were harvested and stained with 2% TTC solution. (b) Representative photographs of brain sections stained with TTC. White region (arrows) indicates the infarct area. (c, d) Quantification graphs of direct infarct volume (c) and edema (d). versus control group. (e, f) Neurological score (e) and wire grip tests (f) were performed to evaluate functional outcomes. versus control group.

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