Pretreatment with Shuanghe-Tang Extract Attenuates Postischemic Brain Injury and Edema in a Mouse Model of Stroke: An Analysis of Medicinal Herbs Listed in Dongui Bogam

Figure 4

Dose-dependent effects of Shuanghe-tang on ischemic brain injury. Mice were pretreated via oral administration of 30, 100, or 300 mg/kg of Shuanghe-tang ( each) or PBS (control group, ) once per day for 4 days prior to ischemic insult, as well as 1 h prior to the procedure. (a) Representative photographs of coronal brain sections stained with TTC. White region (arrows) indicates the infarct area. (b, c) Quantification of direct infarct volume (b) and edema (c) 24 h postischemia. , versus control group. (d–f) Neurological score (d), rota-rod (e), and wire grip (f) results were evaluated to assess recovery of neurologic deficit, locomotor function, and vestibular motor function after ischemic injury. versus control group.

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