Synthesis, Characterization, and Biodistribution of Quantum Dot-Celecoxib Conjugate in Mouse Paw Edema Model

Figure 1

(a) Emission spectra of QD-Celecoxib conjugates (λ_ex = 400 nm and λ_em = 529 nm). Emission spectra showing concentration-dependent fluorescence increase (10 nM > 100 nM > 100 μM > 10 μM > 100 μM) of Celecoxib-conjugated QDs (50 μg/ml) over unconjugated QDs (50 μg/ml). (b) FT-IR spectra of QD-Celecoxib conjugates with shifting of peak from 1640 cm⁻¹ (C=O) to 1540 cm⁻¹ showing the occupancy of Celecoxib of QD-drug conjugates against unconjugated MPA-capped QDs. (c) ¹³C solid-state NMR of Celecoxib, MPA-capped QDs, and QD-Celecoxib conjugate. Spectra of QD-Celecoxib conjugate (bottom) showing more number of carbons in comparison to Celecoxib (centre) and QDs alone (top), which forms an indirect confirmation of conjugation between Celecoxib and QDs.

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