Dysfunction of Nrf2-ARE Signaling Pathway: Potential Pathogenesis in the Development of Neurocognitive Impairment in Patients with Moderate to Severe Obstructive Sleep Apnea-Hypopnea Syndrome
Table 13
Multiple linear regression of age, sex, education, smoking index, PSG parameters, and Trx levels to the prediction of the NAB: maze test scores.
Mode
Unstandardized coefficients
Standardized coefficients
t
Sig.
95.0% confidence interval for B
B
Std. error
Beta
Lower bound
Upper bound
1 constant
−10.86
27.328
−0.397
0.693
−66.285
44.564
Sex
3.027
2.313
0.174
1.309
0.199
−1.664
7.718
Age (y)
−0.221
0.091
−0.363
−2.446
0.019
−0.405
−0.038
Education (y)
0.579
0.201
0.366
2.882
0.007
0.171
0.986
Smoking index
0.002
0.002
0.132
0.994
0.351
−0.002
0.006
AHI
0.013
0.076
0.044
0.178
0.86
−0.14
0.167
ODI
−0.048
0.07
−0.17
−0.691
0.494
−0.189
0.093
LSaO2
0.018
0.084
0.052
0.22
0.827
−0.152
0.189
MSaO2
0.197
0.261
0.164
0.758
0.453
−0.331
0.726
TSat90
−0.032
0.102
−0.094
−0.31
0.768
−0.239
0.175
REM%
−0.056
0.144
−0.059
−0.389
0.699
−0.348
0.236
Trx
0.538
0.261
0.288
2.061
0.047
0.009
1.068
Dependent variable: NAB: maze score. Trx, thioredoxin; AHI, apnea-hypopnea index; ODI, oxygen desaturation index; LSaO2, lowest oxygen saturation; MSaO2, mean oxygen saturation; TSat90, % of time SaO2 < 90%; REM%, percent of rapid eye movement in total sleep time.
