GRP78 Promotes Neural Stem Cell Antiapoptosis and Survival in Response to Oxygen-Glucose Deprivation (OGD)/Reoxygenation through PI3K/Akt, ERK1/2, and NF-κB/p65 Pathways

Figure 7

Diagram of GRP78-mediated NSC survival from OGD/reoxygenation-induced apoptosis through PI3K/Akt, ERK1/2, and NF-κB/p65. GRP78 in NSCs is triggered by OGD/reoxygenation. The signalling is transmitted through PI3K/Akt, ERK1/2, and NF-κB/p65 to cellular antiapoptosis and survival. Meanwhile, the activated PI3K/Akt and ERK1/2 in turn improve GRP78 upregulation. In summary, the bidirectional signalling transductions of GRP78-PI3K/Akt and GRP78-ERK1/2 and the one-way signalling transductions through GRP78 to NF-κB/p65 would contribute essentially to NSC survival from OGD/reoxygenation-induced apoptosis.