Exposure to Ti4Al4V Titanium Alloy Leads to Redox Abnormalities, Oxidative Stress, and Oxidative Damage in Patients Treated for Mandible Fractures

Table 4

Correlations of redox biomarkers in control group and patients with titanium mandibular fixations.

Control group
TOS Man	OSI Man	0.551	0.033
TAC Man	UA plasma	0.425	0.043
GPx erythrocytes	FRAP plasma	0.737	0.037
TAC plasma	GSH plasma	0.608	0.003
8-OHdG plasma	AOPP plasma	0.559	0.047
Study group
UA Man	FRAP Man	0.519	0.019
TAC Man	AGE Man	0.450	0.031
4-HNE Man	OSI Man	0.592	0.043
8-OHdG Man	AGE Man	0.883	0.000
TOS Man	OSI Man	0.567	0.034
AGE Man	GPx erythrocytes	0.574	0.025
TOS Man	CAT erythrocytes	0.515	0.043
8-OHdG Man	GPx erythrocytes	0.781	0.002
TAC Man	UA plasma	0.425	0.043
4-HNE Man	GSH plasma	0.662	0.019
GSH Man	GSH plasma	0.417	0.048
SOD erythrocytes	AGE plasma	0.470	0.020
TAC plasma	AOPP plasma	0.695	0.000
TOS plasma	AOPP plasma	0.529	0.000
TOS plasma	GSH plasma	0.645	0.002
8-OHdG plasma	GSH plasma	0.589	0.044

4-HNE: 4-hydroxynonenal protein adducts; 8-OHdG: 8-hydroxydeoxyguanosine; AGE: advanced glycation end products; AOPP: advanced oxidation protein products; CAT: catalase; FRAP: ferric reducing ability of plasma; GPx: glutathione peroxidase; GSH: reduced glutathione; Man: mandible; OSI: oxidative stress index; SOD: superoxide dismutase-1; TAC: total antioxidant status; TOS: total oxidant status; UA: uric acid.