Effect of the Antioxidant Lipoic Acid in Aortic Phenotype in a Marfan Syndrome Mouse Model

Figure 9

Western blot for pERK1/2/total ERK1/2. Quantitative protein expression analysis in the aortic arch (a), thoracic aorta (b), and abdominal aorta (c) of wild-type (WT) and Marfan syndrome (MFS) mice untreated or treated with losartan or lipoic acid. ^a versus WT losartan treatment; ^b versus MFS untreated; ^c versus WT untreated; ^d versus MFS losartan treatment; ^e versus WT untreated; ^f versus WT losartan treatment; ^g versus WT lipoic acid treatment; ^h versus MFS losartan treatment. Data expressed in mean ± SEM.

(a)

(b)

(c)