Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia

Figure 4

Reduction of the infarct volumes and mortality by TRPML1 activation. (a, b) Infarct volumes of mice infusion with or without 5 μM ML-SA1after 12 hrs reperfusion (). (b) was the statistics for (a). (c) Evaluation of neurological deficit after 24 hrs reperfusion was evaluated in mice infusion with or without 5 μM ML-SA1 (). (d) Evaluation of the survival rate in mice infusion with or without 5 μM ML-SA1 after tBCCAO (). All data were presented as mean ± SEM. All comparisons between groups for statistical significance were performed with one-way analysis of variance (ANOVA) with Tukey’s post hoc test. versus Ctrl. versus OGD.

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