SS-31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain Injury

Figure 1

Administration of SS-31 showed neuroprotection after TBI. (a) The mice were grouped into sham, TBI, TBI + vehicle, and TBI + SS-31. The injection doses of SS-31 were 5 mg/kg and 10 mg/kg. The brain samples were collected 24 h post-TBI to evaluate the water content. Both 5 and 10 mg/kg decreased the water content compared with the TBI + vehicle group; however, there was no significant difference between the two doses. per group. (b) The grip test score in the SS-31 (5 mg/kg as the effective dose) administration group was significantly upregulated than that in the vehicle group. per group. (c, d) The long-term recovery indicator p-eIF2α was restored after treatment with SS-31. Relative protein levels were normalized to the level of β-actin and then were measured by ImageJ. Data are presented as mean ± SEM; versus the sham group; , , versus the TBI + vehicle group.

(a)

(b)

(c)

(d)