Nucleoredoxin-Dependent Targets and Processes in Neuronal Cells

Figure 2

Subcellular localization of Nrx in SH-SY5Y cells and dopaminergic neurons of the mouse CNS. Immunocytochemistry stained for Nrx (green) and nuclei (blue in (b) and (d)) or tyrosine hydroxylase (yellow in (f)), analyzed by confocal microscopy. (a, b) SH-SY5Y control cells. (c, d) SH-SY5Y cells 72 hours after the beginning of neuron-like differentiation induced by retinoic acid. (e, f) Nrx staining in the substantia nigra of the mouse; dopaminergic neurons were labeled for tyrosine hydroxylase (yellow).

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