Nucleoredoxin-Dependent Targets and Processes in Neuronal Cells

Table 2

Potential Nrx targets identified by all three approaches. The table contains the 51 proteins that were identified in all three experiments, i.e., the differential thiol labeling in Nrx-depleted SH-SY5Y cells, and the intermediate trapping using SH-SY5Y and mouse brain extracts. The proteins are sorted alphabetically; full lists can be found in the supplementary material.

Protein ID	Gene name	Protein name
P49588	AARS	Alanine-tRNA ligase, cytoplasmic
P23526	AHCY	Adenosylhomocysteinase
P49419	ALDH7A1	Alpha-aminoadipic semialdehyde dehydrogenase
P04075	ALDOA	Fructose-bisphosphate aldolase A
P48444	ARCN1	Coatomer subunit delta
P54687	BCAT1	Branched-chain amino acid aminotransferase, cytosolic
P78371	CCT2	T-Complex protein 1 subunit beta
P50990	CCT8	T-Complex protein 1 subunit theta
P23528	CFL1	Cofilin-1
Q00610	CLTC	Clathrin heavy chain 1
O94760	DDAH1	N(G),N(G)-Dimethylarginine dimethylaminohydrolase 1
P26641	EEF1G	Elongation factor 1-gamma
P13639	EEF2	Elongation factor 2
P09104	ENO2	Gamma-enolase
P21333	FLNA	Filamin-A
Q16658	FSCN1	Fascin
P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase
P62873	GNB1	Guanine nucleotide-binding protein
P17174	GOT1	Aspartate aminotransferase, cytoplasmic
P00505	GOT2	Aspartate aminotransferase, mitochondrial
Q92769	HDAC2	Histone deacetylase 2
Q99714	HSD17B10	3-Hydroxyacyl-CoA dehydrogenase type-2
P07900	HSP90AA1	Heat shock protein HSP 90-alpha
Q9NSE4	IARS2	Isoleucine-tRNA ligase, mitochondrial
P12268	IMPDH2	Inosine-5-monophosphate dehydrogenase 2
Q07866	KLC1	Kinesin light chain 1
P28838	LAP3	Cytosol aminopeptidase
P55209	NAP1L1	Nucleosome assembly protein 1-like 1
P12955	PEPD	Xaa-Pro dipeptidase
P14618	PKM	Pyruvate kinase
P62937	PPIA	Peptidyl-prolyl cis-trans isomerase A
P53041	PPP5C	Serine/threonine-protein phosphatase 5
Q06830	PRDX1	Peroxiredoxin-1
Q9H6Z4	RANBP3	Ran-binding protein 3
P54136	RARS	Arginine-tRNA ligase, cytoplasmic
P39023	RPL3	60S ribosomal protein L3
P36578	RPL4	60S ribosomal protein L4
P61247	RPS3A	40S ribosomal protein S3a
Q16181	SEPT7	Septin-7
P37837	TALDO1	Transaldolase
P60174	TPI1	Triosephosphate isomerase
Q71U36	TUBA1A	Tubulin alpha-1A chain
Q9BVA1	TUBB2B	Tubulin beta-2B chain
Q16881	TXNRD1	Thioredoxin reductase 1, cytoplasmic
P62987	UBA52	Ubiquitin-60S ribosomal protein L40
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N
P45974	USP5	Ubiquitin carboxyl-terminal hydrolase 5
Q99536	VAT1	Synaptic vesicle membrane protein VAT-1 homolog
Q96QK1	VPS35	Vacuolar protein sorting-associated protein 35
P54577	YARS	Tyrosine-tRNA ligase, cytoplasmic
P63104	YWHAZ	14-3-3 protein zeta/delta (protein kinase C inhibitor protein 1)