Inhibition of TRPA1 Attenuates Doxorubicin-Induced Acute Cardiotoxicity by Suppressing Oxidative Stress, the Inflammatory Response, and Endoplasmic Reticulum Stress

Figure 2

Inhibition of TRPA1 ameliorates cardiac function in mice treated with Dox. (a, b) The body weight (BW) and heart weight (HW) in different groups (). (c, d) The serum levels of cardiotoxicity markers, including creatine kinase isoenzymes (CK-MB) and lactate dehydrogenase (LDH) (). (e, f) The echocardiographic parameters in different groups (). (g) The pathological structure indicated by HE staining (scale bar, 50 μm) (). compared with the CTRL group. compared with the Dox group. EF: ejection fraction; FS: fractional shortening.

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